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Saturday, April 30, 2016

Abhishek D Chouhan

Psoriasis

Psoriasis

Psoriasis is regarded as an autoimmune disease in which genetic and environmental factors have a significant role. The name of the disease is derived from Greek word “psora‟ which means „itch‟. Psoriasis is a non-contagious, dry, inflammatory and ugly skin disorder, which can involve entire system of person.

Psoriasis is a chronic, relapsing, papulosquamous dermatitis characterized by abnormal hyperproliferation of the epidermis. It affects approximately 1.5% to 2% of the population in the western countries. Psoriasis onset can occur at any age, including birth, but there are two peaks, one in teenagers, around 15-20 years of age, and another in the elderly, 55-60 years of age. There are no significant differences in the incidence of psoriasis in male and female patients.

Several distinct but overlapping clinical variants have been identified, but chronic plaque-type lesions are most common. Psoriatic plaques are characterized by a marked keratinocyte hyperproliferation, altered differentiation, and keratin expression, and they are associated with dermal and epidermal infiltration of leukocytes.

Psoriasis has very significant psychosocial morbidity which appears independent of objective disease severity. It is also associated with an increased risk of cardiovascular disease and mortality. Indeed patients with psoriasis have almost twice the risk of cardiovascular disease when compared with normal controls.

The disorder is a chronic recurring condition which varies in severity from minor localized patches to complete body coverage. Fingernails and toenails are frequently affected. Psoriasis can also cause inflammation of the joints, which is known as psoriatic arthritis. Almost 10 to 15 percent of people with psoriasis have psoriatic arthritis. Psoriasis does not show a static clinical picture, lesions grow and regress. New lesions start as small pinpoint papillae. In the early phase, the papules unite, become confluent, and form plaques.

Abhishek D Chouhan

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